Comparison of Monoglyceryl Acetoacetate and Glucose as Parenteral Energy Substrate after Experimental Trauma

作者:

KirveläO.K.Takala, J.A.

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摘要:

The effects of ketone bodies and glucose on nitrogen balance and liver protein synthesis were studied in rat after experimental trauma. Energy was delivered intravenously as either monoglyceryl acetoacetate (MA; 87.5% of total energy input) or glucose (G). The isocaloric infusions (132 kcal/kg/day) were started after recovery from anaesthesia and continued for 2 days. The liver protein synthesis was then measured in vitro by perfusion with 14C-leucine. The infusion of MA resulted in a more negative cumulative nitrogen balance (MA: -2.31 ± 0.26 g N/kg, G: -1.32 ± 0.43 g N/kg/48 h; mean ± SD) and liver protein synthesis (MA: 43.4 ± 17.2, G: 71.1 ± 15.2; arbitrary units, mean ± SD). The results indicate no benefits from MA during the immediate post-traumatic period.

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DOI:

10.1159/000128509

被引量:

2

年份:

1986

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