Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
摘要：
Without a doubt, rodent models have been instrumental in describing pathways that lead to pancreatic beta-destruction, evaluating potential causes of and providing proof-of-principle for the potential of immune-based interventions. However, despite more than two decades of productive research, we are still yet to define an initiating autoantigen for the disease, to determine the precise mechanisms of beta-destruction in and to design interventions that prevent or cure . In this Perspective article, we propose that a major philosophical change would benefit this field, a proposition that is based on evaluation of situations in which rodent models have provided useful guidance and in which they have led to disappointments.
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DOI：
10.1038/nri1502
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