Tumor metastasis: mechanistic insights and clinical challenges.
摘要：
Metastatic disease is the primary cause of death for most cancer patients. Complex and redundant pathways involving the tumor cell and the microenvironment mediate tumor invasion at the primary site, survival and arrest in the bloodstream, and progressive outgrowth at a distant site. Understanding these pathways and their dynamic interactions will help identify promising molecular targets for cancer therapy and key obstacles to their clinical development.
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关键词：
Animals Humans Neoplasms, Experimental Neoplasm Metastasis Capillary Permeability Gene Expression Regulation, Neoplastic Neoplasm Invasiveness Neoplasms Neovascularization, Pathologic Neoplastic Cells, Circulating
DOI：
10.1038/nm1469
被引量：
年份：
2006
Elsevier
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