Expression of Neuroendocrine Cell Markers l-Dopa Decarboxylase, Chromogranin A, and Dense Core Granules in Human Tumors of Endocrine and Nonendocrine Origin

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作者：

AF Gazdar，LJ Helman，MA Israel，EK Russell，RI Linnoila，JL Mulshine，HM Schuller，JG Park

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摘要：

We evaluated the usefulness of decarboxylase () as a marker of neuroendocrine (NE) by measuring its expression in 432 of diverse types and origins. A subset of these and cell lines derived from them also were studied for expression of two other general NE cell markers, () and (DCG). High concentrations of were present in 96 of 117 (82%) recognized to be of NE or neural origin. As expected, not recognized to be of NE cell origin, as well as , , , , and , lacked expression. Of interest, modest concentrations of were present in 46 of 220 (21%) nonendocrine , especially non-small cell lung and . We studied concordant expression of the three NE cell markers in lung and and cell lines. In both types there was nearly 100% concordance between and DCG expression. There was an excellent correlation between and expression in , both small cell and non-small cell, but positive usually lacked expression. We conclude: (a) is an excellent cellular marker for of the NE cell system; (b) about 20% of not of NE cell origin, especially non-small cell lung and , express , suggesting a common endodermal origin of all of the respiratory and gastrointestinal mucosal cells; and (c) and DCG are expressed concordantly, indicating that expression may be used as a substitute for ultrastructural examination of for DCG expression.

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关键词：

Humans Neurosecretory Systems Cytoplasmic Granules Aromatic-L-Amino-Acid Decarboxylases Dopa Decarboxylase Nerve Tissue Proteins Microscopy, Electron Tumor Markers, Biological Cell Differentiation Chromogranin A