Metabolic design for cyanobacterial chemical synthesis

来自 EBSCO

喜欢 0

阅读量：

117

作者：

JWK Oliver，S Atsumi

展开

摘要：

Photosynthetic chemical production in cyanobacteria is a promising technology for renewable energy, CO2 mitigation, and fossil fuel replacement. Metabolic engineering has enabled a direct biosynthetic process from CO2 fixation to chemical feedstocks and biofuels, without requiring costly production, storage, and breakdown of cellulose or sugars. However, direct production technology is challenged by a need to achieve high-carbon partitioning to products in order to be competitive. This review discusses principles for the design of biosynthetic pathways in cyanobacteria and describes recent advances in relevant genetic tools. This field is at a critical juncture in assessing the strength and feasibility of carbon partitioning. To address this, we have included the stoichiometry of reducing equivalents and carbon conservation for heterologous pathways, and a method for calculating product yields against a theoretical maximum.

展开

关键词：

Metabolic engineering Cyanobacteria Carbon fixation Chemical feedstocks Biofuel

DOI：

10.1007/s11120-014-9997-4

被引量：

年份：

2014