Pharmacokinetics and analgesic effect of ketamine in man
摘要：
The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 μg kg 1 and 250 μg kg 1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml 1 . Ketamine was distributed rapidly (T z =17 min). The elimination half-life was 186 min.
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DOI：
10.1093/bja/53.1.27
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Elsevier
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万方医学
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掌桥科研
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