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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

来自 Semantic Scholar

阅读量：

380

作者：

S Aggarwal，N Ghilardi，MH Xie，FJD Sauvage，AL Gurney

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摘要：

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion. IL-23 also induced expression of the related cytokine IL-17F. IL-23 is a heterodimeric cytokine and shares a subunit, p40, with IL-12. In contrast to IL-23, IL-12 had only marginal effects on IL-17 production. These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.

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关键词：

Animals Mice, Inbred C57BL Mice CD4-Positive T-Lymphocytes Cells, Cultured Interleukins Lymphocyte Activation Interleukin-23 Interleukin-23 Subunit p19 Interleukin-17

DOI：

10.1074/jbc.M207577200

被引量：

5375

年份：

2003

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来源期刊

Journal of Biological Chemistry
1/17/2003

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2010
被引量：629

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