N-[2-(4-carboxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethane amine, the methyl ester, salt and stereoisomeric forms thereof

阅读量:

15

申请(专利)号:

EP19870307446

申请日期:

1987-08-24

公开/公告号:

EP0262785A1

公开/公告日期:

1988-04-06

申请(专利权)人:

BEECHAM GROUP PLC

发明人:

AA TrevorSD GlynnAJR Sanders

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被引量:

26

摘要:

N-[2-(4-carboxymethoxyphenyl)-1-(R)-1-methylethyl]-2-(R)-2-hydroxy 2-(3-chlorophenyl)ethanamine or the methyl ester thereof, or a pharmaceutically acceptable salt thereof, ('the RR-isomer') optionally in admixture with N-[2-(4-carboxymethoxyphenyl)-1-(S)-1-methylethyl]-2-(S)-2-hydroxy-2-(3 chlorophenyl)ethanamine, or the methyl ester thereof, or a pharmaceutically acceptable salt thereof, ('the SS-isomer') wherein the SS-isomer forms less than 50% by weight of the mixture of the RR- and SS- isomers; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds and compositions in medicine and agriculture.

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