摘要：

There are disclosed processes for proparing biodegradable collagen-based matrices in sponge or sheet form wherein a liquid substrate is mixed with a collagen selected from the group consisting of types 1, 2 and 3 collagens to form a collagen-based substrate, which is contacted with a cross-linking agent selected from the group consisting of a carbodiimide and succinimidyl active ester and which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix, into which is incorprated a carrier compound selected from the group consisting of types 4 and 5 collagen, fibronectin, laminin, hyaluronate, proteoglycan, epidermal growth factor, platelet derived growth factor, angiogenesis factor, antibiotic, antifungal agent, spermacidal agent, enzyme and enzyme inhibitor.

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