The anaplastic lymphoma kinase in the pathogenesis of cancer.
摘要：
Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine kinases have been shown to have a well-defined pathogenetic role in lymphomas. The anaplastic lymphoma kinase (ALK) is the oncogene of most anaplastic large cell lymphomas (ALCL), driving transformation through many molecular mechanisms. In this Review, we will analyse how translocations or deregulated expression of ALK contribute to oncogenesis and how recent genetic or pharmacological tools, aimed at neutralizing its activity, can represent the basis for the design of powerful combination therapies.
展开
关键词：
Humans Lymphoma Lymphoma, T-Cell Protein-Tyrosine Kinases Lymphoma, Large B-Cell, Diffuse Receptor Protein-Tyrosine Kinases Translocation, Genetic
DOI：
10.1038/nrc2291
被引量：
年份：
2008
Taylor & Francis
Nature
(全网免费下载)
Nature
EBSCO
万方
查看更多
掌桥科研
dx.doi.org
NCBI
NCBI
Europe PMC
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
scienceopen.com
embomm.embopress.org
mct.aacrjournals.org
readcube.com
science-open.com
deepdyve.com
pubget.com
ftp.palgrave-journals.com
pubfacts.com
mendeley.com
f1000.com
onAcademic
cghjournal.org
go.galegroup.com
aperto.unito.it
pharmrev.aspetjournals.org
haematologica.org
www.socolar.com
courses.bio.unc.edu
(全网免费下载)
molbiolcell.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
