摘要：

Objective To investigate the tumor angiogenesis in squamous cell carcinoma of cervix and its clinical significance.Methods The microvessel density(MVD) labeled by CD34,proliferation index(PI) labeled by MIB-1 and lymphatic microvessel density(LMVD) labeled by VEGFR-3 protein in 28 cases of normal cervical epithelium(NCE),36 cases of cervical intraepithelial neoplasm(CIN) and 68 cases of squamous cell carcinoma of cervix(SCC) were detected by immunohistochemistry method.Results The MVD labeled by CD34 in NCE,CIN and SCC groups was 6.3±2.9,18.0±4.7 and 58.2±19.6,respectively.The MVD increased remarkably from NCE to CIN and then to SCC accordingly(P0.01).The MVD in CIN group was positively correlated with PI(r=0.373,P=0.025),but not correlated with LMVD(r=0.138,P=0.421).The MVD in SCC group was both not correlated with PI and LMVD(PI: r=-0.033,P=0.790;LMVD: r=0.114,P=0.354).In SCC group,the MVD positively correlated with depth of stroma involvement(P0.01),but not correlated with patients age,FIGO staging,histological grading,pelvic lymph node metastasis,intravascular infiltration and survival rate(P0.05).In the cases with deeper stroma involvement,the MVD was significantly higher than those without the conditions mentioned above(P0.01).Conclusions The over-expression of MVD may promote atypical cells proliferation of CIN and cancer cells invasion and metastasis of SCC.

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