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Wolbachia and the biological control of mosquito-borne disease.

来自 EBSCO

阅读量：

119

作者：

Iturbe-Ormaetxe, I?aki， Walker, Thomas， O\" Neill, Scott L

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摘要：

Top of pageIntroduction Wolbachia pipientis and disease control Wolbachia transfer into A. aegypti mosquitoes Wolbachia interference with viruses and parasites Molecular genetics of Wolbachia Wolbachia invasion of mosquito populations Fitness of Wolbachia -infected mosquitoes From the lab to the field Future perspectives Acknowledgements Conflict of Interest References Biography Mosquito-borne diseases such as malaria, dengue fever and filariasis cause an enormous health burden to people living in tropical and subtropical regions of the world. Despite years of intense effort to control them, many of these diseases are increasing in prevalence, geographical distribution and severity, and options to control them are limited. The transinfection of mosquitos with the maternally inherited, endosymbiotic bacteria Wolbachia is a promising new biocontrol approach. Fruit fly Wolbachia strains can invade and sustain themselves in mosquito populations, reduce adult lifespan, affect mosquito reproduction and interfere with pathogen replication. Wolbachia -infected Aedes aegypti mosquitoes have been released in areas of Australia in which outbreaks of dengue fever occur, as a prelude to the application of this technology in dengue-endemic areas of south-east Asia.

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关键词：

Aedes aegypti Chikungunya dengue Drosophila Wolbachia pipientis

DOI：

10.1038/embor.2011.84

被引量：

396

年份：

2011

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