c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
摘要：
Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.
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关键词：
Animals Mice Mice, Mutant Strains Macrophages Hematopoietic Stem Cells Cells, Cultured Osteopetrosis Proto-Oncogene Proteins c-fos Osteogenesis Bone Remodeling
DOI：
10.1126/science.7939685
被引量：
年份：
1994
BMJ
Wiley
万方医学
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