Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

来自 EBSCO

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作者：

Y Kurosawa，H Von Boehmer，W Haas，H Sakano，A Trauneker，S Tonegawa

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摘要：

The finding that the diversity (D) and joining (JH) but not the variable (VH) DNA segments of mouse immunoglobulin heavy-chain genes are joined in the DNA of some cloned cytolytic T cells, led to identification and sequencing of three different D DNA segments. Two segments identified on the embryo DNA carry on both the 5' and 3' sides two sets of characteristic sequences separated by a 12-base pair spacer, which have been implicated as recognition signals for a recombinase. The third segment, identified in a form joined with a JHDNA segment in a T cell, carries the recognition signal on the 5' side. These results support the 12/23-base pair model for somatic generation of immunoglobulin V genes, and rule out the possibility that the cytolytic T cells use assembled VH, D and JH sequences to encode their antigen receptors.

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关键词：

MARGINAL ADAPTATION POLYMERIZATION RESTORATIVE RESIN TEETH, FILLINGS

DOI：

10.1038/290565a0

被引量：

835

年份：

1981