Differential visualization of dopamine D2 and D3 receptors in rat brain
摘要：
The mRNA for the dopamine D 3 receptor is confined to limbic regions and the D 3 receptor may be a target for antipsychotic medications. We used quinpirole and domperidone to try to visualize D 3 and dopamine D 2 receptors selectively in rat brain, using in vitro autoradiography and digital subtraction. We used 125 I-sulpiride, a ligand with high affinity for the D 2 receptor in brain and for the D 3 and D 2 receptors in transfected cells. Our data indicate that the D 2 receptor is present in much greater density than the D 3 receptor in rat brain, even in limbic regions.
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关键词：
data visualisation learning (artificial intelligence pattern clustering self-organising feature maps component planes data clustering machine learning data sets metro map metaphor metro visualisation self-organising maps
DOI：
10.1016/0014-2999(93)90963-I
被引量：
年份：
1993
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