Gene Families: The Taxonomy of Protein Paralogs and Chimeras

来自 NCBI

阅读量:

83

作者:

S HenikoffEA GreeneS PietrokovskiP BorkTK AttwoodL Hood

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摘要:

Ancient duplications and rearrangements of protein-coding segments have resulted in complex gene family relationships. Duplications can be tandem or dispersed and can involve entire coding regions or modules that correspond to folded protein domains. As a result, gene products may acquire new specificities, altered recognition properties, or modified functions. Extreme proliferation of some families within an organism, perhaps at the expense of other families, may correspond to functional innovations during evolution. The underlying processes are still at work, and the large fraction of human and other genomes consisting of transposable elements may be a manifestation of the evolutionary benefits of genomic flexibility.

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DOI:

10.1126/science.278.5338.609

被引量:

853

年份:

1997

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来源期刊

Science
1997-10-24

引用走势

1999
被引量:77

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