摘要：

Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. As part of our ongoing search for new antitumour metabolites produced by microorganisms from marine organisms, gymnastatins A (1)-H (8) have been isolated from a strain of Gymnasella dankaliensis originally separated from the marine animal Halichondria japonica. Furthermore, pericosines A (11), B (12), macrosphelides E (13) and F (14) have been isolated from a strain of Periconia byssoides separated from the marine animal Aplysia kurodai. The stereostructures of these metabolites have been elucidated by spectroscopic analyses and some chemical transformations. Among these compounds, 1-3, 6, 7, 11 and 12 exhibited significant cytotoxicity against cultured P388 cells.

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