Transglutaminase is essential in receptor-mediated endocytosis of |[alpha]|2-macroglobulin and polypeptide hormones
摘要：
The receptor-mediated endocytosis of α 2 -macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.
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关键词：
Animals Rats Cell Line Amines Peptides gamma-Glutamyltransferase Hormones alpha-Macroglobulins Membrane Proteins Contact Inhibition
DOI：
10.1038/283162a0
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