Signal Transduction by the JNK Group of MAP Kinases
摘要：
MAP kinases are evolutionarily conserved proteins that are activated by a protein kinase cascade, including a MAP kinase kinase kinase, which phosphorylates a MAP kinase kinase, which in turn activates the MAP kinase by phosphorylation on Thr and Tyr residues. The primary sequence surrounding these phosphorylation sites serves to distinguish three major groups of mammalian MAP kinases. These include the Ras-activated ERK MAP kinases, which are characterized by the sequence TEY and the two stress-activated MAP kinases: p38 with the sequence TGY, and the c-Jun NH 2 -terminal kinases (JNK) with the sequence TPY. This review will focus on the JNK group of MAP kinases.
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关键词：
Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinase 10 Apoptosis MAP Kinase Signaling System Protein-Tyrosine Kinases Morphogenesis Neoplasms
DOI：
10.1007/978-3-0348-8468-6_2
被引量：
年份：
2000
Elsevier
Springer
dx.doi.org
Cell Press
Europe PMC
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