Cooperative interaction between c-myc and bcl-2 proto-oncogenes
摘要：
THE bcl -2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene in tumour progression 1 . The mechanism of synergy is unclear but bcl -2 expression inhibits apoptosis 2–6 , a property presumably pertinent to its proto-oncogenic mode of action 4 . We have shown that the c-myc gene is a potent inducer of apoptosis, in addition to its established role in mitogenesis 7 . Here we show that expression of the bcl -2 protein, Bcl-2, specifically abrogates c-mvoinduced apoptosis without affecting the c-myc mitogenic function. This provides a novel mechanism for oncogene cooperation, of potential importance both in carcinogenesis and in the evolution of drug resistance in tumours.
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关键词：
Cell Line Fibroblasts Neoplasms Estradiol Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Receptors, Estrogen Immunoblotting Immunohistochemistry Mitosis
DOI：
10.1038/359554a0
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年份：
1992
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