摘要：

Mushrooms have become attractive as a functional food and an important source of
newlinephysiologically beneficial medicines and nutraceuticals. They are ubiquitous in nature and produce various classes of biologically active primary and secondary metabolites. Among them, mushrooms in the genus Phellinus have received great attention recently due to its long history of use in oriental countries and its medicinal values for the treatment of many diseases such as stomachaches, inflammation, arthritis, gastroenteric dis-orders, tumors and lymphatic disorders. Phellinus rimosus is a parasitic host specific polypore mushroom often found growing on jack fruit tree trunks in Kerala. It is a less extensively studied species of the genus Phellinus. No study has been carried out on its antidiabetic and
newlinehypolipidemic effect of this mushroom. Thus, in the current study, the aqueous ethanol
newline(70%) extract of P. rimosus was evaluated for their antidiabetic and hypolipidemic effects.
newlineAgain, the in vitro antioxidant activities, toxicity studies, and phytochemical analysis of the extract were also examined. The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern. Diabetes mellitus is a complex and a multifaactorial group of disorders that disturbs the metabolism of carbohydrates, fat and protein. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction and failure of various organs. Diabetic complications arise partly from glycosylation damage to structural and functional proteins and reflect chronic failure to maintain blood glucose homeostasis. Other complications such as retinopathy, neuropathy and cardiomyopathy prevail as a result of hyperglycemia. The present study was aimed to investigate the effects of aqueous ethanolic extract of P. rimosus on streptozotocin (STZ) and alloxan induced diabetes in rats by measuring fasting blood glucose, serum insulin, lipid profiles (atherogenic index)

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