Ethanol inhibits NMDA-activated ion current in hippocampal neurons.
摘要：
The ion current induced by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH). Inhibition increased in a concentration-dependent manner over the range 5 to 50 mM, a range that also produces intoxication. The amplitude of the NMDA-activated current was reduced 61 percent by 50 mM EtOH; in contrast, this concentration of EtOH reduced the amplitude of current activated by the glutamate receptor agonists kainate and quisqualate by only 18 and 15 percent, respectively. The potency for inhibition of the NMDA-activated current by several alcohols is linearly related to their intoxicating potency, suggesting that alcohol-induced inhibition of responses to NMDA receptor activation may contribute to the neural and cognitive impairments associated with intoxication.
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关键词：
Humans Hippocampus Neurons Ethanol 1-Butanol Pentanols Methanol Chlorides gamma-Aminobutyric Acid Quisqualic Acid
DOI：
10.1126/science.2467382
被引量：
年份：
1989
万方医学
NCBI
JSTOR
Oxford Univ Press
NCBI
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