Clonal cell lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses
摘要：
Tissue culture cell lines highly sensitive to both N- and B-tropic host-range variants of mouse-tropic murine leukemia virus (MuLV) were derived by clonal selection from a feral mouse embryo cell culture line. The clonal lines are more sensitive than standard assay cultures, particularly for isolating naturally occurring N- and B-tropic MuLV from tissue extracts. Also, they can support the replication of xenotropic MuLV to a limited extent. The host-range patterns of N- and B-tropic viruses are not altered by serial passage in the sensitive cells. It is presumed that these cell lines lack the Fv-1 gene function, and it is suggested that Fv-1 may have a much broader inhibitory effect than previously recognized.
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关键词：
Animals Mice Cell-Free System Cell Line Leukemia Virus, Murine Virus Cultivation Plaque Assay Virus Replication Genetic Variation Clone Cells
DOI：
10.1016/0042-6822(75)90013-6
被引量：
年份：
1975
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