The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery
摘要：
Positive selection to self-MHC/peptide complexes has long been viewed as a device for skewing the T cell repertoire toward recognition of foreign peptides presented by self-MHC molecules. Here, we provide evidence for an alternative possibility, namely, that the self-peptides controlling positive selection in the thymus serve to maintain the longevity of mature T cells in the periphery. Surprisingly, when total T cell numbers are reduced, these self-ligands become overtly stimulatory and cause naive T cells to proliferate and undergo homeostatic expansion.
展开
关键词：
Animals Mice T-Lymphocytes Peptides Receptors, Antigen, T-Cell Histocompatibility Antigens Class II Homeostasis Lymphocyte Activation Cell Survival Mice, Transgenic
DOI：
10.1016/S1074-7613(00)80092-8
被引量：
年份：
1999
Elsevier
Elsevier
(全网免费下载)
国家科技图书文献中心
(权威机构)
Semantic Scholar
掌桥科研
查看更多
Europe PMC
Cell Press
NCBI
NCBI
Cell Press
(全网免费下载)
ResearchGate
ResearchGate
(全网免费下载)
ProQuest
EBSCO
www.socolar.com
scienceopen.com
mysciencework.com
cghjournal.org
en.zl50.com
jimmunol.org
pubfacts.com
bbmt.org
genome.cshlp.org
mendeley.com
学术范
(全网免费下载)
core.ac.uk
(全网免费下载)
学术范
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
