摘要：

The growth and morphology of fibroblasts cultured on various polymer substrates, as well as their , were studied. A clear difference in cell growth and cell morphology was observed among the substrates. The dependence of cell growth on the water contact angle of substrate was similar to that of the . Fibroblasts could proliferate at the highest rate and showed the highest-ordered morphology when cultured on the substrate with a contact angle around 70 degrees, which was also the most favorable for . The amount of synthesized by total cells and of adsorption of the synthesized to substrates were in good correlation with the cell growth dependence on the contact angle of substrate, whereas the synthesis per cell was more active on the surfaces poor for cell growth than on the good ones. Cells on surfaces promoting active synthesis had a round shape and clustered upon each other. The -immobilized surface had nearly the highest , high , and high adsorption among the substrates studied. In addition, the highest-ordered morphology and no lag time for proliferation were observed for the -immobilized surface. These results indicate that the -immobilized substrate provides the most favorable surface for cell growth at the initial stage.

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