Functions of lncRNA HOTAIR in lung cancer.
摘要：
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognosis. Moreover, HOTAIR promotes proliferation, survival, invasion, metastasis, and drug resistance in lung cancer cells. Here we review the molecular mechanisms underlying HOTAIR-mediated aggressive phenotypes of lung cancer. We also discuss HOTAIR's potential in diagnosis and treatment of lung cancer, as well as the challenges of exploiting HOTAIR for intervention of lung cancer.
展开
DOI：
10.1186/s13045-014-0090-4
被引量：
年份：
2014
Springer
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
BioMed Central
(全网免费下载)
Pubmed Central
(全网免费下载)
查看更多
BioMed Central
(全网免费下载)
ResearchGate
(全网免费下载)
EBSCO
Citeseer
(全网免费下载)
scienceopen.com
(全网免费下载)
core.ac.uk
(全网免费下载)
jhoonline.org
(全网免费下载)
Springer
(全网免费下载)
Semantic Scholar
(全网免费下载)
Pubmed Central
(全网免费下载)
BioMed Central
(全网免费下载)
Europe PMC
(全网免费下载)
BioMed Central
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
core.ac.uk
(全网免费下载)
scienceopen.com
(全网免费下载)
jhoonline.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
