Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
摘要：
Nerve growth factor (NGF) induces both differentiation and survival of neurons by binding to the Trk receptor protein tyrosine kinase. Although Ras is required for differentiation, it was not required for NGF-mediated survival of rat pheochromocytoma PC-12 cells in serum-free medium. However, the ability of NGF to prevent apoptosis (programmed cell death) was inhibited by wortmannin or LY294002, two specific inhibitors of phosphatidylinositol (Pl)-3 kinase. Moreover, platelet-derived growth factor (PDGF) prevented apoptosis of PC-12 cells expressing the wild-type PDGF receptor, but not of cells expressing a mutant receptor that failed to activate Pl-3 kinase. Cell survival thus appears to be mediated by a Pl-3 kinase signaling pathway distinct from the pathway that mediates differentiation.
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关键词：
Programmed cell death Trk protooncogene product Pc12 cells Neuronal differentiation Tyrosine kinase Factor receptor Pheochromocytoma cells Pdgf receptor Binding site Map kinase
DOI：
10.1126/science.7701324
被引量：
年份：
1995
Taylor & Francis
BMJ
掌桥科研
万方医学
dx.doi.org
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