Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex
摘要：
Four novel steroidal alkaloids named cortistatins E (1), F (2), G (3), and H (4) have been isolated from the marine sponge Corticium simplex. The chemical structures of these four cortistatins, which are unique abeo-9(10–19)-stigmastane-type steroidal alkaloids having oxabicyclo[3.2.1]octene and N-methyl piperidine or 3-methylpyridine units in the side chain, were elucidated by the detailed 2D-NMR analysis. These four compounds showed only weak anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) at 0.35–1.9 μM concentrations in contrast to cortistatin A (5), which was isolated as a highly selective inhibitor of proliferation of HUVECs from the same marine sponge.Graphical abstractFour novel steroidal alkaloids, cortistatins E, F, G, and H were isolated from the marine sponge Corticium simplex and their chemical structures were elucidated by 2D-NMR analysis.
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DOI：
10.1016/j.tet.2007.02.112
被引量：
年份：
2007
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