Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos - ScienceDirect
摘要：
In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/wingless, porcupine, frizzled, beta-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.
展开
关键词：
Blastomeres Endoderm Animals Caenorhabditis elegans Cytoskeletal Proteins Adenomatous Polyposis Coli Protein Trans-Activators Caenorhabditis elegans Proteins Insect Proteins Drosophila Proteins
DOI：
10.1016/S0092-8674(00)80531-0
被引量：
年份：
1997
Elsevier
Elsevier
(全网免费下载)
万方医学
Semantic Scholar
(全网免费下载)
掌桥科研
查看更多
dx.doi.org
NCBI
BioMed Central
Cell Press
Europe PMC
NCBI
EureKaMag.com
(全网免费下载)
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
yadda.icm.edu.pl
(全网免费下载)
core.ac.uk
(全网免费下载)
osti.gov
(全网免费下载)
jacionline.org
www4.utsouthwestern.edu
emboj.embopress.org
molbiolcell.org
cghjournal.org
escholarship.umassmed.edu
mysciencework.com
mendeley.com
deepdyve.com
mcb.asm.org
umassmed.edu
(全网免费下载)
readcube.com
scienceopen.com
umassmed.edu
(全网免费下载)
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
EureKaMag.com
(全网免费下载)
ResearchGate
(全网免费下载)
core.ac.uk
(全网免费下载)
yadda.icm.edu.pl
(全网免费下载)
umassmed.edu
(全网免费下载)
osti.gov
(全网免费下载)
umassmed.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
