Nanoemulsion Components Screening and Selection: a Technical Note

来自 EBSCO

喜欢 0

阅读量：

150

作者：

A Azeem，M Rizwan，FJ Ahmad，Z Iqbal，RK Khar，M Aqil，S Talegaonkar

展开

摘要：

INTRODUCTION Nanoemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water, and surfactants with a droplet size usually in the range of 10–100nm ( 1 , 2 ). Their long-term stability, ease of preparation (spontaneous emulsification), and high solubilization of drug molecules make them promising as a drug delivery tool. They have found wide applications in oral drug delivery to enhance the solubility and bioavailability of the lipophilic drugs ( 3 – 5 ). Recently, there has been a surge in the exploration of nanoemulsions for transdermal delivery ( 6 – 8 ). They are also being investigated ardently for potential applications in ocular ( 9 , 10 ), pulmonary ( 11 ), nasal ( 12 , 13 ), vaginal ( 14 , 15 ), and parenteral drug delivery ( 16 – 18 ). The use of nanoemulsions in drug delivery has been reviewed, and it was noted that most studies have not been very systematic with regard to selection of surfactants and cosurfactants. The main objective of this study was to provide an ...INTRODUCTIONNanoemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water, and surfactants with a droplet size usually in the range of 10–100nm ( 1 , 2 ). Their long-term stability, ease of preparation (spontaneous emulsification), and high solubilization of drug molecules make them promising as a drug delivery tool. They have found wide applications in oral drug delivery to enhance the solubility and bioavailability of the lipophilic drugs ( 3 – 5 ). Recently, there has been a surge in the exploration of nanoemulsions for transdermal delivery ( 6 – 8 ). They are also being investigated ardently for potential applications in ocular ( 9 , 10 ), pulmonary ( 11 ), nasal ( 12 , 13 ), vaginal ( 14 , 15 ), and parenteral drug delivery ( 16 – 18 ).Nanoemulsions12356891011121314151618The use of nanoemulsions in drug delivery has been reviewed, and it was noted that most studies have not been very systematic with regard to selection of surfactants and cosurfactants. The main objective of this study was to provide an ...

展开

关键词：

cosurfactant nanoemulsions pseudoternary phase diagram solubility surfactant toxicity tolerability