摘要：

The reaction of ethyl orthoformate with alkylamines in the presence of acetic acid has been shown to lead to N′,N′-dialkylformamidines in good yield. Under similar conditions ethyl orthoacetate gives N,N′'-dialkylacetamidines. Reaction of ethyl orthoacetate with one mole of an aromatic amine, preferably in the presence of acetic acid, gives an ethyl N-arylacetimidate, while reaction with two moles of an aromatic amine in the presence of acetic acid gives an N,N′-diarylacetamidine. The role of the acetic acid in these reactions is discussed.

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