Solubility-modulated monolithic osmotic pump tablet for atenolol delivery
摘要：
The optimal monolithic osmotic pump tablet was found to be able to deliver atenolol at the rate of approximate zero-order up to 24h, independent of release media and agitation rate. The approach of solubility-modulated by acid-alkali reaction might be used for the preparation of osmotic pump tablet of other poorly water-soluble drugs with alkaline or acid groups.
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DOI：
10.1016/j.ejpb.2007.04.020
被引量：
年份：
2008
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