Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives
摘要：
A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed.
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DOI：
10.1016/j.ejmech.2011.10.018
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年份：
2012
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来源期刊
European journal of medicinal chemistry
2012-01-16
引用走势
2015
被引量：14
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