Molecular biology of muscle development

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摘要：

The small soil nematode Caenorhabditis elegans is an attractive organism in which to apply biochemical and genetic approaches to the study of muscle development and function. Only two major muscles are present in the organism—the pharyngeal muscle and the body wall muscle—and the anatomy and lineage of all the muscle cells in the organism throughout development is known (Sulston et al ., 1983; Sulston and Horvitz, 1977). Because a large fraction of the nematode tissue mass is muscle, the major contractile proteins can be isolated in milligram quantities from a few liters of nematode culture (Epstein et al .,1974; Waterston et al ., 1977; Harris and Epstein, 1977; MacLeod et al ., 1977 a,b ; Zengel and Epstein, 1980 c ). Caenorhabditis elegans exhibits a characteristic swimming pattern on the surface of agar plates. Genetic analysis (Brenner, 1974) defined mutations in more than 100 different genes that produce animals with defective motility (the uncoordinated or unc phenotype). Mutations in 25 of these unc genes produce gross abnormalities in muscle ultrastructure (Waterston et al .,1980; Zengel and Epstein, 1980 b ).

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关键词：

Animals Muscles Transcription Factors Myogenic Regulatory Factors MyoD Protein DNA-Binding Proteins Muscle Development Base Sequence Cell Division Cell Differentiation