摘要：

Examines the effect of the p53 tumor suppressor gene on angiogenesis. Use of fibroblasts cultured from Li-Fraumeni patients; Switch of normal cells to an angiogenic phenotype as they progress toward malignancy to attract the nourishing vasculature that they depend on for their growth; Ability of p53 to stimulate the endogenous thrombospondin-1 gene.

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