Cellular Oncogenes and Retroviruses

来自 NCBI

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阅读量：

113

作者：

Bishop，J M

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摘要：

Evidence is mounting that cellular oncogenes are involved in tumorigenesis, whatever its proximal cause. Some of these genes may serve to initiate the genesis of tumors, some to sustain the final neoplastic phenotype, some may serve either purpose in different contexts. Cellular oncogenes appear not to be tumorigenic in their native state; they must either be activated to abnormal levels of expression, or mutated so as to change some aspect of their function. Based on present evidence, either of these mechanisms may apply. The recognition and isolation of cellular oncogenes has set the stage for fresh assaults on the mechanisms of carcinogenesis. The role of DNA damage can now be examined directly and the nature of the damage explored. The number of genetic functions required for the genesis of an individual tumor may become clear. The genes responsible for heritable predispositions to cancer can be sought. We hope to discern the variety and nature of the biochemical functions that can drive a cell to cancerous growth. The design of definitive strategies for the prevention or cure of human malignancy may have to await all of these accomplishments.

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关键词：

Animals Humans Retroviridae Neoplasms Cell Transformation, Neoplastic Transduction, Genetic Transfection Phylogeny Mutation Genes, Viral