摘要：

Objective To investigate the effect of oxaliplatin on invasion and metastasis of human endometrial cancer cell(HEC-1A). Methods HEC-1A cell lines were stably cultured in vitro,and then were administered with different concentrations of oxaliplatin(40,80,160μg/ml)for 72h.The effect of oxaliplatin on invasive capability of HEC-1A was assessed using a Transwell method.The effect of oxaliplatin on adhesive capability of HEC-1A was determinated by the reconstituted basement membrane assay;the effect of oxaliplatin on migration ability of HEC-1A was detected through the scratch testing. Results Compared with the untreated control group,oxaliplatin(40,80,160μg/ml)significantly inhibited HEC-1A invasion,while the rate of invasive inhibition was increased(P0.01).And it reduced the migrative ability of tumor cells(P0.01).In addition,oxaliplatin markedly attenuated the migration condition of HEC-1A(P0.01). Conclusion Oxaliplatin effectively inhibited the secondary invasion and metastasis of endometrial cancer cells,thus exerting anti-cancer role.

展开