Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
摘要：
The discovery that breakdown products of cellular sphin-golipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction. Sphin-golipids and lysophingolipids affect significant cellular responses and exhibit antitumor promoter activities in various mammalian cells. These molecules may function as endogenous modulators of cell function and possibly as second messengers.
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DOI：
10.1126/science.2643164
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年份：
1989
Wiley
万方医学
Semantic Scholar
Europe PMC
NCBI
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来源期刊
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1996
被引量：153
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