Discovery of novel N -substituted carbazoles as neuroprotective agents with potent anti-oxidative activity
摘要:
Structurally diversified carbazoles were screened to anti-oxidative assays in two cell models.Novel N-tolyl substituted carbazole derivative 6 significantly prevented cell death induced by glutamate or HCA.Compound 6 potently attenuated the glutamate-induced ROS production.Compound 6 did not restore the GSH in HT22 cells exposed to glutamate.
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DOI:
10.1016/j.ejmech.2013.07.029
被引量:
年份:
2013
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