摘要：

Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water‐affinity or ‐solubility were considered unsuitable for asymmetric synthesis. <img class="figure__image" src="https://wol-prod-cdn.literatumonline.com/cms/attachment/0a8a6857-7489-4698-bb39-3816d466fab6/mcontent.gif" data-lg-src="https://wol-prod-cdn.literatumonline.com/cms/attachment/fad062cb-bb00-450b-883b-ded544b3da64/mcontent.jpg">

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