摘要：

Glycyl-L-prolyl-L-leucyl-glycyl-L-proline and its related compounds were synthesized for elucidating the substrate specificity of collagenase. In the synthetic study, almost all of the possible routes were tried and the yield. crystallizability and specific rotation of products were compared for each route. Peptides or their derivatives containing two proline residues in general were hydrophilic and hard to be crystallized, but it was found, that carbobenzoxyglycyl-L-prolyl-L-leucyl-glycyl-L-proline was an exceptional example of a readily crystallizable substance and a good substrate for collagenase.

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