Use of TGF-beta antagonists to treat or to prevent chronic transplant rejection

阅读量:

22

申请(专利)号:

10/348665

申请日期:

01/21/2003

公开/公告号:

US20030180301

公开/公告日期:

2003-01-01

发明人:

S KeshavjeeGeorge St., Judith A.M Liu

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被引量:

144

摘要:

Effective use of a TGF-β antagonist to treat or to prevent loss of transplant function is described herein. Use of a TGF-β antagonist is demonstrated to effectively prevent loss of organ function in a host due to chronic rejection in which TGF-β-mediated fibroproliferation is a characteristic. Expression in situ of a TGF-β antagonist in the form of a recombinant receptor, i.e., TGF-β type III receptor (TGFBIIIR) showed prevention of bronchiolitis obliterans in comparison to untreated controls in a rat lung transplant model. This provides an effective method for preventing or inhibiting chronic rejection of transplant organs such as lung, kidney, liver and hear in vertebrate hosts including human hosts.

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