Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas using two-dimensional genomic scanning and amplification mapping of sequence tagged sites
摘要：
Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenocarcinoma. Amplified genomic NotI-HinfI fragments were identified by...
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DOI：
10.1038/87174
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年份：
2001
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2003
被引量：22
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