Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
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65
摘要：
Using gene targeting techniques, mice that have been generated with two germ–linenull alleles (homozygotes) develop normally but are highly susceptible to early onset spontaneous tumours. Here, we show that mice with a single nullallele (heterozygotes) produced in the same way are also susceptible to spontaneous tumours, but with a delayed onset compared to homozygotes. The most frequent tumour type in homozygotes was malignant lymphoma; in heterozygotes, osteosarcomas and soft tissue sarcomas predominated. Heterozygous mice treated with a liver carcinogen, dimethylnitrosamine, showed a decreased survival time in comparison to treated wild type mice, suggesting that the p53–deficient mice may be useful for somecarcinogenesis assays.
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关键词：
Animals Mice, Inbred C57BL Mice Neoplasms, Experimental Homozygote Genes, p53 Dimethylnitrosamine Male Heterozygote
DOI：
10.1038/ng1193-225
被引量：
年份：
1993
BMJ
Nature
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Nature
Springer
万方医学
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