Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States
摘要：
Primary cutaneous marginal zone B-cell lymphoma is considered the cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Although its molecular pathogenesis is currently unknown, an etiological link withinfection has been identified in European, but not in American or Asian cases. To better understand the pathogenesis and the geographical differences of cutaneous marginal zone B-cell lymphoma, 60 cases from the East Asia, Germany, and the United States at their initial presentation were subjected to the following analyses; (1) clinicopathological comparison between the geographical regions, (2) detection ofDNA, (3) detection of thefusion transcript, a gene alteration specific to mucosa-associated lymphoid tissue lymphoma, and (4) inactivation of tumor suppressor genes (death-associated protein kinase (),,,,,, and) by hypermethylation of the CpG islands. Cases from the three geographical regions showed similar clinicopathological features. However, moderate/marked tissue eosinophilia was found in 9/25 Asian cases, but only 1/23 German cases (=0.011) and 0/12 American cases (=0.015). All 60 cases were negative for eitherDNA orfusion. Tumors from the three regions were highly methylated for(38–50% of the cases, mean 43%) and(42–70%, mean 49%), and the positivities were significantly higher than those of nonneoplastic skin (8%,=0.0010 and 14%,=0.0032, respectively). Methylation of these genes had no significant association with progressive features of the tumor. Primary cutaneous marginal zone B-cell lymphomas from the three geographical regions have common clinicopathological features, however, moderate/marked tissue eosinophilia is a feature found almost exclusively in Asian cases.infection andfusion are not significant in this tumor. Methylation ofandgenes is a frequent event in this lymphoma at its initial presentation, but may not be associated with tumor progression.
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关键词：
primary cutaneous marginal zone B-cell lymphoma molecular and clinicopathological study international study
DOI：
10.1038/modpathol.2008.159
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Springer
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