Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
摘要：
Protein-tyrosine phosphatases (PTPases) have been implicated in the physiological regulation of the insulin signalling pathway. In cellular and molecular studies, the transmembrane, receptor-type PTPase LAR and the intracellular, non-receptor enzyme PTP 1B have been shown to have a direct impact on insulin action in intact cell models. Since insulin signalling can be enhanced by reducing the abundance or activity of specific PTPases, pharmaceutical agents directed at blocking the interaction between individual PTPases and the insulin receptor may have potential clinical relevance to the treatment of insulin-resistant states such as obesity and Type II diabetes mellitus.
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关键词：
insulin action transmembrane signalling insulin resistance tyrosine kinase insulin receptor receptor internalization
DOI：
10.1023/A:1006812218502
被引量：
年份：
1998
Springer
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