Enantiomeric Separation of 2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid by High Performance Capillary Electrophoresis
摘要：
The enantiomers of 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid were successfully separated by high performance capillary electrophoresis using HP-β-CD as a chiral selector.Effects of the pH and concentration of buffer,concentration of HP-β-CD,type and concentration of organic modifier on the resolution of enantiomers were investigated.Under the optimized conditions pH=9.10 60 mmol/L of phosphate buffer solution,35.7 mmol/L HP-β-CD and 5% CH3OH,the enantiomers of 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid were separated baseline.Calibration curve was linear over the range of 5～160 μg/mL,and the limit of detection was 1.01 μg/mL for target analyte.
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DOI：
10.1016/S1872-2067(10)60172-6
被引量：
年份：
2011
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