摘要：

The enantiomers of 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid were successfully separated by high performance capillary electrophoresis using HP-β-CD as a chiral selector.Effects of the pH and concentration of buffer,concentration of HP-β-CD,type and concentration of organic modifier on the resolution of enantiomers were investigated.Under the optimized conditions pH=9.10 60 mmol/L of phosphate buffer solution,35.7 mmol/L HP-β-CD and 5% CH3OH,the enantiomers of 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid were separated baseline.Calibration curve was linear over the range of 5～160 μg/mL,and the limit of detection was 1.01 μg/mL for target analyte.

展开