Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
摘要：
The presence of social support has been associated with decreased stress responsiveness. Recent animal studies suggest that the neuropeptide oxytocin is implicated both in prosocial behavior and in the central nervous control of neuroendocrine responses to stress. This study was designed to determine the effects of social support and oxytocin on cortisol, mood, and anxiety responses to psychosocial stress in humans. In a placebo-controlled, double-blind study, 37 healthy men were exposed to the Trier Social Stress Test. All participants were randomly assigned to receive intranasal oxytocin (24 IU) or placebo 50 min before stress, and either social support from their best friend during the preparation period or no social support. Salivary free cortisol levels were suppressed by social support in response to stress. Comparisons of pre- and poststress anxiety levels revealed an anxiolytic effect of oxytocin. More importantly, the combination of oxytocin and social support exhibited the lowest cortisol concentrations as well as increased calmness and decreased anxiety during stress. Oxytocin seems to enhance the buffering effect of social support on stress responsiveness. These results concur with data from animal research suggesting an important role of oxytocin as an underlying biological mechanism for stress-protective effects of positive social interactions.
展开
DOI：
10.1016/S0006-3223(03)00465-7
被引量：
年份：
2003
Taylor & Francis
Elsevier
BMJ
万方医学
Semantic Scholar
(全网免费下载)
查看更多
Ingenta
dx.doi.org
NCBI
APA
Oxford Univ Press
NCBI
Cell Press
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
EBSCO
readcube.com
psycho.unibas.ch
(全网免费下载)
portal.uni-freiburg.de
(全网免费下载)
unibe.ch
(全网免费下载)
soz.psy.unibe.ch
(全网免费下载)
学术范
(全网免费下载)
学术范
faculty.buffalostate.edu
(全网免费下载)
钛学术
scienceopen.com
frontiersin.org
钛学术
(全网免费下载)
boris.unibe.ch
zora.uzh.ch
edoc.unibas.ch
onAcademic
ajp.psychiatryonline.org
psychologie.uni-freiburg.de
(全网免费下载)
biologicalpsychiatryjournal.com
mendeley.com
rstb.royalsocietypublishing.org
pubfacts.com
journals.elsevierhealth.com
deepdyve.com
psyneuen-journal.com
core.ac.uk
mysciencework.com
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
unibe.ch
(全网免费下载)
学术范
(全网免费下载)
钛学术
(全网免费下载)
faculty.buffalostate.edu
(全网免费下载)
portal.uni-freiburg.de
(全网免费下载)
psychologie.uni-freiburg.de
(全网免费下载)
psycho.unibas.ch
(全网免费下载)
soz.psy.unibe.ch
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
