How nascent phagosomes mature to become phagolysosomes
摘要：
Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its membrane and contents that culminates in the formation of phagolysosomes. Maturation entails orderly sequential fusion of the phagosomal vacuole with specialized endocytic and secretory compartments. Concomitantly, the phagosomal membrane undergoes both inward and outward vesiculation and tubulation followed by fission, thereby recycling components and maintaining its overall size. Here, we summarize what is known about the molecular machinery that governs this complex metamorphosis of phagosome maturation.
展开
关键词：
phagocytosis phagosome maturation phosphoinositide GTPase calcium autophagy membrane fusion membrane fission
DOI：
10.1016/j.it.2012.03.003
被引量：
年份：
2012
Elsevier
国家科技图书文献中心
(权威机构)
Wiley
掌桥科研
Semantic Scholar
查看更多
Ingenta
dx.doi.org
Europe PMC
NCBI
NCBI
Cell Press
Cell Press
(全网免费下载)
dialnet.unirioja.es
ResearchGate
ResearchGate
(全网免费下载)
ProQuest
EBSCO
学术范
molbiolcell.org
clinicalkey.com
pubfacts.com
mendeley.com
jcs.biologists.org
onAcademic
www.socolar.com
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
