SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein
摘要：
Helicobacter pylori CagA protein is associated with severe gastritis and gastric carcinoma. CagA is injected from the attached Helicobacter pylori into host cells and undergoes tyrosine phosphorylation. Wild-type but not phosphorylation-resistant CagA induced a growth factor-like response in gastric epithelial cells. Furthermore, CagA formed a physical complex with the SRC homology 2 domain (SH2)-containing tyrosine phosphatase SHP-2 in a phosphorylation-dependent manner and stimulated the phosphatase activity. Disruption of the CagA-SHP-2 complex abolished the CagA-dependent cellular response. Conversely, the CagA effect on cells was reproduced by constitutively active SHP-2. Thus, upon translocation, CagA perturbs cellular functions by deregulating SHP-2.
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关键词：
Gastric Mucosa COS Cells Cell Membrane Animals Humans Helicobacter pylori Phosphotyrosine Intracellular Signaling Peptides and Proteins Dipeptides Bacterial Proteins
DOI：
10.1126/science.1067147
被引量：
年份：
2002
BMJ
万方医学
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